Publications: 2005-current

877) K. Shiomi, H. Ui, H. Suzuki, H. Hatano, T. Nagamitsu, D. Takano, H. Miyadera, T. Yamashita, K. Kitao, H. Miyoshi, A. Harder, H. Tomoda, and S. Ōmura: A γ-lactone form of nafuredin, nafuredin-γ, also inhibits helminth complex I. J. Antibiot., 58, 50-52 (2005).

878) K. Shiomo, R. Matsui, M. Isozaki, H. Chiba, T. Sugai Y. Yamaguchi, R. Masuma, H. Tomoda, T. Chiba, H. Yan, Y. Kitamura, W. Sugiura, S. Ōmura, and H. Tanaka: Fungal phenalenones inhibit HIV-1 integrase. J. Antibiot., 58, 65-68 (2005).

879) K. Shiomi, K. Hatae, H. Hatano, A. Matsumoto, Y. Takahashi, C.-L. Jiang, H. Tomoda, S. Kobayashi, H. Tanaka, and S. Ōmura. A new antibiotic, antimycin A9, produced by Streptomyces K01-003. J. Antibiot., 58, 74-78 (2005).

880) K. Yoshida, T. Sunazuka, K. Nagai, A. Sugawara, A. Cho, T. Nagamitsu, Y. Harigaya, K. Otoguro, K. S. Akagawa, and S. Ōmura. Macrolides with promotive activity of monocyte to macrophage differentiation. J. Antibiot., 58, 79-81 (2005).

881) T. Sunazuka, T. Shirahata, S. Tsuchiya, T. Hirose, R. Mori, Y. Harigaya, I. Kuwajima, and S. Omura. A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Org. Lett., 7, 941-943 (2005).

882) T. Sunazuka, K. Yoshida, N. Kojima, T. Shirahata, T. Hirose, M. Handa, D. Yamamoto, Y. Harigaya, I. Kuwajima, and S. Ōmura: Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline. Tetrahedron Lett., 46, 1459-1461 (1005).

883) A. Takahashi, J. Inokoshi, H. Chiba, S. Ōmura, and H. Tanaka: Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomycete. Arch. Biochem. Biophys., 437, 233-240 (2005).

884) T. Fukuda, A. Matsumoto, Y. Takahashi, H. Tomoda, and S. Omura: Phenatic acids A and B, new potentiators of antifungal miconazoole activity produced by Streptomyces sp. K03-0132. J. Antibiot., 58, 252-259 (2005).

885) T. Sunazuka, P. A. Sprengeler, A. B. Smith, III, and S. Omura: Absolute stereochemistries and total synthesis of (+/)(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion. Tetrahedron, 61, 3789-3803 (2005).

886) T. Fukuda, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura: Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot., 58, 309-314 (2005).

887) T. Fukuda, H. Tomoda, and S. Ōmura: Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation. J. Antibiot., 58, 315-321 (2005).

888) N. Koyama, T. Nagahiro, Y. Yamaguchi, T. Ohshiro, R. Masuma, H. Tomoda, and S. Ōmura: Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840. J. Antibiot., 58, 339-345 (2005).

889) R. Uchida, R. Imasato, Y. Yamaguchi, R. Masuma, K. Shiomi, H. Tomoda, and S. Omura: New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778. J. Antibiot., 58, 339-345 (2005).

890) T. Hirose, T. Sunazuka, D. Yamamoto, N. Kojima, T. Shirahata, Y. Harigaya, I. Kuwajima, and S. Ōmura: Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation. Tetrahedron, 61, 6015-6039 (2005).

891) F. V. Rao, D. R. Houston, R. G. Boot, J. M. Aerts, M. Hodkinson, J. Adams, K. Shiomi, S. Ōmura, and D. M. F. van Aalten: Specificity and affinity of natural products cyclopentapeptide inhibitors against A. fumigatus, human and bacterial chitinases. Chem. & Biol., 12, 65-76 (2005).

892) H. Matsui, M. Eguchi, K. Ohsumi, A. Nakamura, Y. Isshiki, K. Sekiya, Y. Kikuchi, T. Nagamitsu, R. Masuma, T. Sunazuka, and S. Ōmura: Azithromycin inhibits the formation of flagellar filaments without suppressing flagelin synthesis of Salmonella enterica serovar typhimurium. Antimicrob. Agents and Chemother., 49, 3396-3403 (2005).

893) H. Ui, S. Asanuma, H. Chiba, A. Takahashi, Y. Yamaguchi, R. Masuma, S. Omura, and H. Tanaka: Mycophenolic acid inhibits syncytium formation accompanied by reduction of gp120 expression. J. Antibiot., 58, 514-518 (2005).

894) M. Shibuya, B. B. Snider, Y. Sakano, H. Tomoda, S. Ōmura, and Y. Ebizuka: Revised structures of Epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929. Antibiot., 58, 590-601 (2005).

895) T. Sunazuka, T. Hirose, and S. Ōmura: Total synthesis of madindolines, potent selective inhibitors, novel bioactive microbial metabolites. J. Synth. Org. Chem., Japan, 63, 1090-1101 (2005).

896) A. Kageyama, Y. Takahashi, T. Seki, H. Tomoda, and S. Ōmura: Oryzihumus leprocrescens gen nov., sp. nov. J. Syst. Evol. Microbiol., 55, 2555- 2559 (2005).

897) T. Nagamitsu, Y. Harigaya, and S. Ōmura: Total synthesis of borrelidin (Review article). Proc. Japan Acad., 81, 244-256 (2005).

898) N. Koyama, T. Nagahiro, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura. Stemphones, novel potentiators of imipenem activity against mechicillin-resistant Staphylococcus aureus, produced by Aspergillus sp. FKI-2136. J. Antibiot., 58, 695-703 (2005).

899) R. Uchida, R. Imasato, K. Shiomi, H. Tomoda, and S. Ōmura: Yaequinones J1 and J2, novel insecticidal antibiotics from Penicillium sp. FKI-2140. Org. Lett., 7, 5701-5704 (2005).

900) H. Gouda, T. Sunazuka, H. Ui, M. Handa, Y. Sakoh, Y. Iwai, S. Hirono, and S. Ōmura: stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics NMR spectroscopy, and the modified Mosher method. Proc. Natl. Acad. Sci. (USA), 102, 18286-18291(2005).

901) T. Sunazuka and S. Ōmura: Total synthesis of α-pyrone meroterpenoids, novel bioactive microbial metabolites. Chem. Rev., 105, 4559-4580 (2005).

902) R. Uchida, R. Imasato, Y. Yamaguchi, R. Masuma, K.Shiomi, H. Tomoda, and S. Ōmura: New insecticial antibiotics, hydroxyfungerins A and B, produced by Metahizium sp. FKI-1079. J. Antibiot., 58, 804-809 (2005).

903) Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura: A new species of Dinemasporium from sugar cane on Irabujima island, Japan. Mycoscience, 46, 367-369 (2005).

904) K. Nagai, T. Doi, T. Sekiguchi, I. Namatame, T. Sunazuka, H. Tomoda, S. Omura, and T. Takahashi: Synthesis and biological evaluation of a beauveriolide analogue library. J. Combinatorial Chem., 8, 103-109 (2006).

905) J. Matsuo, T. Shirahata, and S. Omura: catalytic and stereoselective glycosylation with glycosyl N-trichloro-acetylcarbamate. Tetrahedron Lett., 47, 267-271 2006).

906) R. Uchida, Y.-P. Kim, I. Namatame, H. Tomoda, and S. Ōmura: Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25. J. Antibiot., 59, 93-97 (2006).

907) Y. Takahashi, A. Matsumoto, K. Morisaki, and S. Ōmura: Patulibacer minatonensis gen. nov., sp. nov., a novel actinobacterium isolated using an agar medium supplemented with superoxide dismutase, and proposal of Patulibacteracea fam. nov. Int. J. Syst. Evol. Microbol., 56, 401-406 (2006).

908) H. Gouda, T. Sunazuka, K. Yoshida, A. Sugawara, Y. Sakoh, S. Omura, and S. Hirono: Three-dimensional solution of monocyte-to-macrophage differentiation. Bioorg. Med. Chem. Lett., 16, 2406-2409 (2006).

909) D. Yamamoto, T. Sunazuka, T. Hirose, N. Kojima, E. Kaji, and S. Ōmura: Design, synthesis, and biological activities of madindoline analogues. Bioorg. Med. Chem. Lett., 26, 2807-2811 (2006).

910) R. Horsefield, V. Yankovskaya, G. Sexton, W. Whittingham, K. Shiomi, S. Ōmura, B. Byrne, G. Cecchini, and S. Iwata: Structural and computational analysis of the quinone-binding site of Complex II (Succinate-ubiquinone oxidoreductase). A mechanism of electron stransfer and proton conduction during ubiquinone reduction. J. Biol. Chem., 281, 7309-7316 (2006).

911) M. Iwatsuki, H. Tomoda, R. Uchida, H. Gouda, S. Hirono, and S. Ōmura: Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure. J. Am. Chem. Soc., 128, 7486-7491 (2006).

912) R. Uchida, H. Tomoda, and S. Ōmura: Biosynthesis of sespendole. J. Antibiot., 59, 298-302 (2006).

913) C. N. Tetzlaff, Z. You, D. E. Cane, S. Takamatsu, S. Ōmura, and H. Ikeda: A gene cluster for biosynthesis of sesquiterpenoid antibiotic pantalenolactone in Streptomyces avermitilis. Biochem., 45, 6179-6186 (2006).

914) R. Uchida, Y.-P. Kim, T. Nagamitsu, H. Tomoda, and S. Ōmura: Structure elucidation of fungal sespendole, and an inhibitor of lipid droplet synthesis in macrophages. J. Antibiot., 59, 338-344 (2006).

915) Z. You, S. Ōmura, H. Ikeda, and D. E. Cane: Pentalenolactone biosynthesis, molecular cloning and assignment of biochemical function to ptIH, a non-heme iron dioxygenase of Streptomyces avermitilis. J. Am. Chem. Soc., 128, 6566-6567 (2006).

916) T. Fukuda, Y. Hasegawa, K. Hagimori, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura. Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342. J. Antibiot., 59, 480-485 (2006).

917) T. Hirose, T. Sunazuka, D. Yamamoto, E. Kaji, and S. Ōmura. Synthetoc applications of a three component mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B. Tetrahedron Lett. 48. 6761-6764 (2006).

918) A. Kageyama, Y. Takahashi, and S. Ōmura. Microbacterium deminutum sp. nov., Micobacterium pumilum sp. nov. and Microbacterium aoyamense sp. nov. Int. J. System. Evol. Microbiol., 56, 2113-2117 (2006).

919) T. Shirahata, T. Sunazuka, K. Yoshida, D. Yamamoto, Y. Harigaya, I. Kuwajima, T. Nagai, H. Kiyohara, H. Yamada, and S. Ōmura. Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids. Tetrahedron, 62, 9483-9496 (2006).

920) H. Ui, K. Shiomi, H. Suzuki, H. Hatano, H. Orimoto,Y. Yamaguchi, R. Masuma, K. Sakamoto, K. Kita, H. Miyoshi, H. Tomoda, H. Tanaka, and S. Ōmura: Paecilamminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J. Antibiot., 59, 591-596 (2006).

921) T. Ohshiro, I. Namatame, K. Nagai, T. Sekiguchi, T. Doi, T. Takahashi, K. Akasaka, L. L. Rudel, H. Tomoda, and S. Ōmura: Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers. J. Org. Chem., 71, 7643-7649 (2006).

922) R.Uchida, R. Imasato, Y. Yaguchi, R. Masuma, K. Shiomi, H. Tomoda, and S, Ōmura: Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiot., 59, 646-651 (2006).

923) R. Chida, R. Imasato, H. Tomoda, and S. Ōmura: Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. J. Antibiot., 59, 652-658 (2006).

924) T. Fukuda, Y. Sakabe, H. Tomoda, and S. Ōmura: Fungal citridone D having a novel phenylfuropyridine skeleton. Chem. Pharm. Bull., 54, 1659-1661 (2006).

925) S. Tshuchiya, T. Sunazuka, T. Hirose, R. Mori, T. Tanaka, M. Iwatsuki, and S. Ōmura: Asymmetric total synthesis of (+)-K01-0509B: Determination of absolute configuration. Org. Lett.,, 8, 5577-5580 (2006).

926) S. Monma, T. Sunazuka, K.Nagai, T. Arai, K. Shiomi, R. Matsui, and S. Ōmura: Verticilide: Elucidation of absolute configuration and total synthesis. Organic Lett., 8, 5601-5601 (2006).

927) T. Hirose, T. Sunazuka, Y. Noguchi, Y. Yamaguchi, H. Hanaki, K. B. Sharpless, and S. Ōmura: Rapid eSARf via Click Chemistry: An alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates. Heterocycles, 69, 55-61 (2006).

928) C. Ichino, N. Soonthornchareonnon, W. Chuakul, H. Kiyohara, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, S. Ōmura, and H. Yamada: Screening of Thai medicinal plant extracts and their active constituents for In Vitro antimalarial activity. Phytother. Res., 20, 307-309 (2006).

929) C. Ichino, H. Kiyohara, N. Soonthornchareonnon, W. Chuakul, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, and S. Ōmura, and H. Yamada: Antimalarial activity of biflavonoids from Ochna integerrima. Planta Medica, 72, 611-614 (2006).

930) S, Ōmura: Being fascinated by macrolides for 40 years (Rev. article). Farumashia, 42, 979-983 (2006).

931) C. N. Tetzlaff, Z. You, D. E. Cane, S. Takamatsu, S. Ōmura, and H. Ikeda: A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. Biochemistry, 45, 6179-6186 (2006).

932) H. Ikeda and S. Ōmura: New system for the production of secondary metabolites by a versatile host genetically optimized. (Rev. article). Kagaku to Seibutsu. 44, 391-398 (2006).

933) R. Quaderer, S. Ōmura, H. Ikeda, and D. E. Cane: Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to Ptll, a cytochrome P450 of Streptomyces avermitilis. J. Am. Chem. Soc., 128, 13036-13037 (2006).

934) H. Ui, K. Shiomi, H. Suzuki, H. Hatano, H. Morimoto, Y. Yamaguchi, R. Masuma, T. Sunazuka, H. Shimamura, K. Sakamoto, K. Kita, H. Miyoshi, H. Tomoda, and S. Ōmura: Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. J. Antibiot., 59, 785-790 (2006).

935) T. Hirose, T. Sunazuka, D. Yamamoto, M. Mouri, Y. Hagiwara, T. Matsumaru, E. Kaji, and S. Ōmura: Studies toward the total synthesis of irumamycin: stereoselective preparation of the C(15)-C(27) segment via two-directional chain synthesis. Tetrahedron Lett., 48, 413-416 (2007).

936) A. Matsumoto, Y. Takahashi, Y. Iwai, and S. Ōmura: Isolation of Gram-positive bacteria with high G+C from inside soil aggregates. Actinomycetol., 20, 30-34 (2006).

937) S. Iwasaki and S. Ōmura: Search for protein farnesyltransferase inhibitors of microbial origin; our strategy and results as well as the results obtained by other groups (Rev. article). J. Antibiot., 60, 1-12 (2007).

938) H. Shimamura, T. Sunazuka, T. Izuhara, T. Hirose, K. Shiomi, and S. Ōmura: Total synthesis and biological evaluation of verticipyrone and analogues. Org. Lett., 9, 65-67 (2007).  

939) S. Ōmura: Discovery of Avermectin and its development (Review article). Jpn. J. Antibiot., 59, Suppl. 106-113 (2006).

940) A. Kageyama, Y. Takahashi, and S. Ômura:  Mycobacterium terricolae sp. nov., isolated from soil in Japan.  J. Gen. Appl. Microbiol., 53, 1-5 (2007).

941) H. Sudo, K. Ozaki, H. Muramatsu, K. Kamei, K. Yogo, O. Cynshin, H. Koga, Z. Itoh, S. Ōmura, and H. Takanashi: Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools.  Neurogastroenterol. Motil, 19, 318-326 (2007).

942) H. Ui, A. Ishiyama, H. Sekiguchi, M. Namatame, A. Nishihara, Y. Takahashi, K. Shiomi, K. Otoguro, and S. Ōmura: Selective and potent in vitro antimalarial activities found in four microbial metabolites.  J. Antibiot., 60, 220-222 (2007).

943) T. Nagamitsu, D. Takano, K. Marumoto, T. Fukuda, K. Furuya, K. Otoguro, K. Takeda, I. Kuwajima, Y. Harigaya, and S. Ōmura: Total synthesis of borrelidin.  J. Org. Chem., 72, 2744-2756 (2007).

944) H. Takanashi, K. Yogo, K. Ozaki, H. Koga, Z. Itoh, and S. Ōmura:  In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology, 79, 137-148 (2007).

945) K. Ozaki, H. Sudo, H. Muramatsu, K. Yogo, K. Kamei, H. Koga, Z. Itoh, S. Ōmura, and H. Takanashi:  Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs. Inflammopharmacology, 15, 36-42 (2007).

946) K. Kita, K. Shiomi, and S. Ōmura:  Advances in drug discovery and biochemical studies (Review article):  Trends Parasitol., 23, 223-229 (2007).

947) S. Ōmura and K. Shiomi: Discovery, chemistry, and chemical biology of microbial products (Review article).  Pure Appl. Chem., 79, 581-591 (2007).