PUBLICATIONS
Latest publication
Discovery, chemistry, and chemical biology of microbial products [abstract]
Splendid gifts: Fourth edition
Splendid gifts from microorganisms - the achievements of Satoshi Omura and collaborators. [how to order]
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Publications: 2010-current
1057) N. Koyama, S. Kojima, T. Fukuda, T. Nagamitsu, T. Yasuhara, S. Ōmura, and H. Tomoda: Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent. Org. Lett., 12, 432-435 (2010).
1058) J. Inokoshi, Y. Takagi, R. Uchida, R. Masuma, S. Ōmura, and H. Tomoda: Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J. Antibiot., 63, 9-16 (2010).
1059) K. Shiomi, R. Matsui, A. Kakei, Y. Yamaguchi, R. Masuma, H. Hatano, N. Arai, M. Isozaki, H. Tanaka, S. Kobayashi, A. Turberg, and S. Ōmura: Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J. Antibiot., 63, 77-82 (2010).
1060) R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Ohte, S. Ōmura, and H. Tomoda: Nokosomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J. Antibiot., 63, 151-155 (2010).
1061) R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Ōmura, and H. Tomoda: Nokosomycins, new antibiotics discovered in an in vivo mimic infection model using silkworm larve. II: Structure elucidation.
J. Antibiot., 63, 157-163 (2010).
1062) Koyama, S. Kojima, K. Nonaka, R. Masuma, M. Matsumoto, S. Ōmura and H. Tomoda: Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905. J. Antibiot., 63, 183-186 (2010).
1063) T. Shirahata, J.-I. Matsuo, S. Teruya, N. Hirata, T. Kurimoto, N. Akimoto,T. Sunazuka, E. Kaji, and S. Ōmura: Improved catalytic and stereoselective glycosylation with glycosyl N-trichloro-acetyl- carbamate: application to various 1-hydroxy sugars. Carbohydrate Res., 345 740-749 (2010).
1064) M. Komatsu, T. Uchiyama, S. Ōmura, D. E. Cane, and H. Ikeda: Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl. Acad. Sci., USA, 107, 2646-2651 (2010).
1065) E. Takashima, H. Yamada, A. Yajima, K. Shiomi, S. Ōmura, K. Kiyoshi: A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitans. I. Periodont. Res., 45, 123-128 (2010).
1066) T. Hirose, T. Sunazuka, and S. Ōmura: Recent development of two chitinase inhibitors, argifin and argadin, produced by soil microorganisms (Rev. article). Proc. Jpn. Acad., Ser. B86, 85-102 (2010).
1067) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Sato, M.
Hatsu, H. Iinuma, S. Shibahara, S. Nimura Nimura, S. Kondo, H. Yamada, and S. Ōmura: In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot., 63, 275-277 (2010).
1068) H. Yamazaki, S. Ōmura, and H. Tomoda: Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2. J. Antibiot., 63, 329-330 (2010).
1069) M. Iwatsuki, Y. Kinoshita, M. Niitsuma, H. Hashida, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, and S. Ōmura: Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452. J. Antibiot., 63, 331-333 (2010).
1070) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Shibahara, S. Kondo, H. Yamada, and S. Ōmura: Promising lead compounds for novel antiprotozoals. J. Antibiot., 63, 381-384 (2010).
1071) J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. BNamatame, A. Nishihara-Tsukashima, K. Nonaka, H. Ui, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, and S. Ōmura: Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573. J. Antibiot., 63, 559-561 (2010).
1072) K. Otoguro, A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Nakajima, S. Shibahara, S. Kondo, H. Yamada, and S. Ōmura: In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds. J. Antibiot., 63, 579-581 (2010).
1073) M. Iwatsuki, K. Otoguro, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, J. Hashida, T. Nakashima, R. Masuma, Y. Takahashi, H. Yamada, and S. Ōmura: In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot., 63, 619-622 (2010).
1074) A. Takahashi, J. Inokoshi, M. Tsunoda, K. Suzuki, A. Takenaka, T. Sekiguchi, S. Ōmura, and H. Tanaka: Actinohivin: specific amino acid residues essential for anti-HIV activity. J. Antibiot., 63, 661-665 (2010).
1075) M. Niitsuma, J. Hashida, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi, and S. Ōmura: Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178. J. Antibiot., 63, 673-679 (2010).
1076) T. Nakajima, T. Seki, A. Matsumoto, H. Miura, E. Sato, Y. Niwano, M. Kohno, S. Ōmura, and
Y. Takahashi: Generation of reactive oxygen species from conventional laboratory media. J. Biosci. Bioeng., 110, 304-307 (2010).
1077) Y. Kobayashi, M. Ichioka, T. Hirose, K. Nagai, A. Matsumoto, H. Matsui, H. Hanaki, R. Masuma, Y. Takahashi, S. Ōmura, and T. Sunazuka: Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg. Med. Chem. Lett., 20, 6116-6120 (2010).
1078) H. Yamazaki, S. Ōmura, and H. Tomoda: 6’-Hydroxy-3’-methoxy-mitorubrin, a new potentiator of antifungal miconazole ativity produced by Penicilliim radicum FKI-3765-2. Chem. Pharm. Bull., 58, 829-832 (2010).
1079) H. Gouda, T. Sunazuka, T. Hirose, K. Iguchi, N. Yamaotsu, A. Sugawara, Y. Noguchi, Y. Saito, T. Yamamoto, T. Watanabe, K. Shiomi, S. Ōmura, and S. Hirono: NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclo-pentapeptide chitinase inhibitor argifin. Bioorg. Med. Chem., 18, 5835-5844 (2010).
1080) T. Nagai, Y. Shimizu, T. Shirahata, T. Sunazuka, H. Kiyohara, S. Ōmura, and H. Yamada: Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata. Int. Immunopharmacol., 10, 655-661 (2010).
1081) N. Matoba, A. S. Husk, B. W. Barnett, M. M. Pickel, C. J. Arntzan, D. C.Montefiori, A. Takahashi, K. Tanno, S. Ōmura, H. Cao, J. P. Mooney, C. V. Hanson, and H. Tanaka: HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic ativity. PLOS One, 5, e11143-1-e11143-13 (2010).
1082) H. Yamazaki, N. Koyama, S. Ōmura, and H. Tomoda: New rugulosins, anti-MRSA antibiotics, produed by Penicilliuim radicum FKI-3765-2. Org. Lett., 12, 1572-1575 (2010).
1083) A. Matsumoto, K . Nakai, K. Morisaki, S. Ōmura, and Y. Takahashi: Demequina salsinemoris sp. nov., isolated on agar media supplemented with ascorbic acid or rutin. Int. J. Sys. Evol. Microbiol., 60, 1206-1209 (2010).
1084) Y. Inahashi, A. Matsumoto, H. Danbara, S. Ōmura, and Y. Takahashi:Phytohabitans suffuscus gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae isolated from plant roots.Int. J. Sys. Evol. Microbiol., 60, 2652-2658 (2010).
1085) H. Namikoshi, T. Sunazuka, Y. Kitamura, T. Suzuki, Y Hamasaki, S. Yamazaki, S. Ōmura, and A. Hatamochi: Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts.
Arch. Dermatol. Res., 302, 341-348 (2010).
1086) S. Ikeda, H. Hanaki, C. Yanagisawa, Y. Ikeda-Dantsuji, H. Matsui,
M. Iwatsuki, K. Shiomi, T. Nakae, K. Sunagawa, and S. Ōmura: Identification of the active component that induces vancomycin resistance in MRSA. J. Antibiot., 63, 533-538 (2010).
1087) M. Iwatsuki, S. Takada, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, K. Shiomi, and S. Ōmura: In vitro and in vivo antimalarial activity of puberulic aci and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J. Antibiot., 64, 183-188 (2011).
1088) K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Ōmura, and A. Abe: A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium.
J. Antibiot., 64, 197-203 (2011).
1089) A. Crump and S. Ōmura: Ivermectin, ‘Wonder drug’ from Japan: the human use perspective (Rev. article). Proc. Jpn. Acads., Ser. B, 87, 13-28 (2011).
1090) K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Ōmura, and A. Abe: A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacer rodentium.
J. Antibiot., 64, 197-203 (2011).
1091) Y. Inahashi, A. Matsumoto, S. Ōmura, Y. Takahashi: Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins. J. Antibiot., 64, 297-302 (2011).
1092)Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takashi, S. Ōmura, and K. Shiomi: Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T. J. Antibiot., 64, 303-307 (2011).
1093) A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima,
T. Sunazuka, Y. Takahashi, S. Ōmura, and K. Otoguro: Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum. J. Antibiot., 64, 381-384 (2011).
1094) S. Ohte, D. Matsuda, R. Uchida, K. Nonaka, R. Masuma, S. Ōmura, and
H. Tomoda: Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864. J. Antibiot., 64, 489-494 (2011).
1095) A. Takahashi, J. Inokoshi, A. Hachiya, S. Oka, S. Ōmura, and H. Tanaka:
The high mannose-type glycan binding lectin actinohivin: dimerization greatly
improves anti-HIV activity. J.Antibiot., 64, 551-557 (2011).
1096) H. Oguri, T. Hiruma, Y. Yamagishi, H. Oikawa, A. Ishiyama, K. Otoguro, H. Yamada, and S. Ōmura: Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues.
J. Am. Chem. Soc., 133, 7096-7105 (2011).
1097) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Ōmura, and H. Yamada: In vitro antitrypanosomal activity of plant terpens against Trypanosoma brucei. Phytochemistry, 72, 2024-2030 (2011).
1098) S. Kitani, K. T. Miyamoto, S. Takamatsu, E. Herawati, H. Iguchi, K. Nishitomi, M. Uchida, T. Nagamitsu, S. Ōmura, H. Ikeda, and T. Nihira: Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc. Natl. Acad. Sci., USA, 108, 16410-16415 (2011).
1099) A. Sugawara, A. Sueki, T. Hirose, K. Nagai, H. Gouda, S. Hirono, H. Shima, K. S. Akagawa, S. Ōmura, and T. Sunazuka: Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel lead for anti-inflammatory and/or immunomodulatory agents. Bioorg, & Med. Chem. Lett., 21, 3373-3376 (2011).
1100) T. Miyagawa, K. Nagai, A. Yamada, Y. Sugihara, T. Fukuda, R. Uchida, H. Tomoda, S. Ōmura, and T. Nagamitsu: Total synthesis of citridone A. Org. Lett., 13, 1158-1161 (2011).
1101) H. Matsui, H. Hanaki, M. Inoue, H. Akama, T. Nakae, K. Sunagawa,
and S. Ōmura: Development of an immiunochromatographic strip for simple detection of Penicillin-binding protein 2’∇. Clin. Vacc. Immunol., 18, 248-253 (2011).
1102) K. Nonaka, R. Masuma, M. Iwatsuki, K. Shiomi, K. Otoguro, and S. Ōmura:
Penicillium viticola, a new species isolated from a grape in Japan. Mycoscience 52, 338-343 (2011).
1103) T. Ohshiro, D. Matsuda, K. Sasaki, C. Degirolamo, Hiroaki Yagyu, L. L. Rudel, S. Ōmura, S. Ishibashi, H. Tomoda: Pyripyropene A, an acyl-coenzyme A: cholesterol acyltransferase 2-selective inhibitor, attenuates hyperchol- esterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler. Thromb. Vasc. Biol., 3, 1108-1115 (2011).
1104) S. Ōmura: Microbial metabolites: 45 years of wandering, wondering and discovering. Tetrahedron, 67, 6420-6459 (2011).
1105) T. Shirahata, A. Kojima, S. Teruya, J. Matuo, M. Yokoyama, S. Unagiike, T. Sunazuka, K. Makino, E. Kaji, S. Ōmura, and Y. Kobayashi: Sequential one-pot glycosylation with glycosyl N-trichloroacetylcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars. Tetrahedron, 67, 6482-6496 (2011).
1106) M. Mori, H. Morimoto, Y.-P. Kim, H. Ui, K. Nonaka, R. Masuma, K. Sakamoto, K. Kita, H. Tomoda, K. Shiomi, and S. Ōmura: Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389.
Tetrahedron, 67, 6582-6586 (2011).
1107) T. Hirose, T. Kasai, T. Akimoto, A. Emndo, A. Sugawara, K. Nagasawa,
K. Shiomi, S. Ōmura, T. Sunazuka: Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecycloxy)benzyl tag.
Tetrahedron, 67, 6633-6643 (2011).
1108) M. Iwatsuki, T. Ishimori, T. Yamamoto, K. Takata, M Mori, K. Nonaka, R. Masuma, Y. Hayakawa, H. Hanaki, K. Shomi, and S. Ōmura: Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429. Tetrahedron, 67, 6644-6648 (2011).
1109) T. Hirose, M. Iwatsuki, S. Ōmura, and T. Sunazuka: Isolation, total synthesis and determination of the absolute configuration of guadinomines: potent inhibitors of a bacterial type III secretion system (Rev. article). Journal of Synthetic Organic Chemistry, Japan, 69, 775-788 (2011).